Two molecules are at the forefront of modern longevity research: NMN (nicotinamide mononucleotide) and spermidine. Both occur naturally in the body – and both decline with age. What's behind this?
NMN – Precursor to a vital coenzyme
NMN is a direct precursor to NAD+ (nicotinamide adenine dinucleotide), a coenzyme found in every cell of the body and involved in numerous metabolic processes. NAD+ plays a role in mitochondrial energy production and cellular maintenance processes.
NAD+ levels in the body decrease with age. NMN as a dietary supplement is being studied for its ability to increase NAD+ levels. Dietary supplements are not a substitute for a balanced and varied diet and a healthy lifestyle.
Spermidine – a natural polyamine
Spermidine is an endogenous polyamine found in foods such as wheat germ, legumes, aged cheese, and mushrooms. In the body, spermidine is involved in cellular maintenance processes, including autophagy – a natural process where cells break down and recycle damaged components.
Spermidine concentration in the body decreases with age. Current research is investigating the role an increased spermidine intake through food or supplements can play.
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NMN & Spermidine: Complementary mechanisms of action
NMN and spermidine target different points in cell metabolism:
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NMN supports NAD+ metabolism and thus processes of mitochondrial function.
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Spermidine is involved in the regulation of autophagy – a cellular quality assurance process.
Both substances are being intensively investigated in basic research. Statements about specific health effects in humans require further clinical evidence.
Current study situation
Human studies on NMN show that oral intake can increase NAD+ levels in the blood. Studies on spermidine investigate, among other things, connections with memory and heart health markers. Research is in an active but still early stage – conclusive statements about efficacy in humans are currently not possible.
Note: The studies mentioned in this article are for general information. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease.
Dosage & Intake – Guidance from studies
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NMN: 250–500 mg daily, usually in the morning
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Spermidine: 1–3 mg daily (from wheat germ extract)
Please consult a healthcare professional before taking dietary supplements, especially if you have existing conditions, are pregnant, or are taking medication. This applies equally to customers in Germany, Austria, and Switzerland.
Quality that counts
At Jennifer Frey, we value lab-tested purity, transparent labeling, and products without unnecessary additives – developed for people who want to actively and informedly shape their health.
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* Dietary supplements are not a substitute for a balanced and varied diet and a healthy lifestyle. The recommended daily intake must not be exceeded. Keep out of reach of children.
